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Changes in Bacterial Resistance Patterns of Pediatric Urinary Tract Infections and Rationale for Empirical Antibiotic

İbrahim Gökçe1, Neslihan Çiçek1, Serçin Güven1

  • 1Department of Pediatrics, Division of Pediatric Nephrology, Marmara University School of Medicine, İstanbul, Turkey.

Balkan Medical Journal
|April 27, 2017
PubMed

Insights

Antibiotic resistance in childhood urinary tract infections (UTIs) is increasing for some drugs like cefixime and ciprofloxacin. Periodic evaluation of resistance patterns is crucial for effective empiric antimicrobial therapy in pediatric UTIs.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Urinary tract infections (UTIs) are common in children, with causative agent spectrum and antibiotic resistance patterns influenced by various factors.
  • Understanding these patterns is essential for effective treatment and public health strategies.

Purpose of the Study:

  • To analyze antibiotic resistance trends in pediatric UTIs over time.
  • To compare current resistance patterns with historical data to identify changes.

Main Methods:

  • Retrospective cross-sectional study analyzing Gram-negative bacteria from pediatric UTIs.
  • Comparison of antibiotic resistance data from 2001-2003 (period 1) and 2011-2014 (period 2).

Main Results:

  • Escherichia coli remained the predominant pathogen (60-73%).
  • Significant increasing resistance trends observed for cefixime (1% to 15%), amikacin (0% to 4%), and ciprofloxacin (0% to 3%).
  • Decreasing resistance trend noted for nitrofurantoin (17% to 7%).

Conclusions:

  • Antibiotic resistance in pediatric UTIs necessitates periodic evaluation.
  • Empiric antimicrobial therapy decisions should be guided by current antibiotic sensitivity results.
Abstract

Keywords:
Urinary tract infectionantibiotic resistance children.

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