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Updated: Mar 3, 2026

Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
[Influence of smoking on pharmacokinetics of medication]
1Radboudumc, afd. Apotheek, Nijmegen.
Abstract:
- In a previous issue, a case report was presented in the Dutch Journal of Medicine (NTvG) of a patient who had variable clozapine levels after switching from regular cigarettes to an e-cigarette and vice versa.- Besides clozapine there are a number of other agents with a narrow therapeutic range where pharmacokinetics can be influenced by smoking.- This review describes the mechanisms of smoking-induced influence on the pharmacokinetics of medicines, and guidance will be provided regarding which medicines must be monitored more closely when patients change their smoking habits.- Finally, an overview is given on package insert information concerning dose adjustments for smokers and non-smokers.
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