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Sensitivity, Specificity and Predictive Value of Heart Rate Variability Indices in Type 1 Diabetes Mellitus

Anne Kastelianne França da Silva1, Diego Giuliano Destro Christofaro1, Aline Fernanda Barbosa Bernardo2

  • 1Universidade Estadual Paulista Júlio de Mesquita Filho, Presidente Prudente, SP, Brazil.

Arquivos Brasileiros De Cardiologia
|April 27, 2017
PubMed

Insights

Heart rate variability (HRV) indices reveal autonomic nervous system changes in young individuals with type 1 diabetes mellitus (T1DM). Specific HRV measures accurately differentiate T1DM patients from healthy controls.

Area of Science:

  • Cardiology
  • Endocrinology
  • Autonomic Neuroscience

Background:

  • Heart rate variability (HRV) indices show potential for accurately detecting autonomic dysfunction.
  • Autonomic modulation may be altered in individuals with type 1 diabetes mellitus (T1DM), but research in this area is limited.

Purpose of the Study:

  • To compare HRV indices between young individuals with T1DM and healthy controls.
  • To evaluate the prognostic value of HRV indices using sensitivity, specificity, and predictive values.

Main Methods:

  • A cross-sectional study involving 39 young patients with T1DM and 43 healthy controls.
  • Beat-to-beat HRV was measured for 30 minutes using a Polar S810i heart rate monitor.
  • Multiple HRV indices were calculated, including SDNN, RMSSD, PNN50, TINN, RRTri, LF ms2, HF ms2, LF un, HF un, LF/HF, SD1, SD2, SD1/SD2, and ApEn.

Main Results:

  • Type 1 DM subjects exhibited reduced sympathetic and parasympathetic activities and overall autonomic nervous system variability.
  • Indices such as RMSSD, SDNN, PNN50, LF ms2, HF ms2, RRTri, SD1, and SD2 demonstrated high diagnostic accuracy in distinguishing diabetic individuals.

Conclusions:

  • Individuals with T1DM display altered autonomic modulation.
  • Specific HRV indices (SDNN, RMSSD, PNN50, RRtri, LF ms2, HF ms2, SD1, SD2) can serve as valuable tools for discriminating T1DM patients.
Abstract

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