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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Racial/Ethnic Differences in Left Ventricular Structure and Function in Chronic Kidney Disease: The Chronic Renal

Faraz S Ahmad1, Xuan Cai2, Katherine Kunkel3

  • 1Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

American Journal of Hypertension
|April 27, 2017
PubMed

Insights

Blacks with chronic kidney disease (CKD) have higher rates of left ventricular hypertrophy (LVH), a marker of heart disease. This study found Black race independently associated with concentric LVH in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Medical Genetics

Background:

  • Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk, particularly in Black populations.
  • Left ventricular hypertrophy (LVH) is a key subclinical CVD marker, but its racial variations in CKD patients are understudied.

Purpose of the Study:

  • To compare the prevalence of different left ventricular (LV) remodeling types across racial/ethnic groups in individuals with CKD.
  • To determine if race/ethnicity is independently associated with specific LV remodeling patterns, adjusting for confounders.

Main Methods:

  • Cross-sectional analysis of the Chronic Renal Insufficiency Cohort Study.
  • Compared LV geometry types (concentric hypertrophy, eccentric hypertrophy, concentric remodeling) between non-Hispanic Black and non-Hispanic White participants.
  • Utilized multinomial logistic regression to assess independent associations between race/ethnicity and LV remodeling.

Main Results:

  • Identified 1,164 non-Hispanic Black and 1,155 non-Hispanic White participants with adequate echocardiogram data.
  • Non-Hispanic Blacks exhibited higher mean LV mass index and a greater prevalence of concentric LVH compared to non-Hispanic Whites.
  • Black race/ethnicity was independently linked to increased odds of concentric LVH, even after accounting for factors like blood pressure and antihypertensive medication use.

Conclusions:

  • Significant racial differences in LV mass and hypertrophic morphology exist among CKD patients.
  • Findings highlight potential contributors to racial disparities in CVD outcomes within the CKD population.
  • Further research is warranted to investigate the impact of LVH prevalence on CVD disparities in CKD.
Abstract

Keywords:
blood pressureechocardiographyhypertensionleft ventricular hypertrophyrace and ethnicityremodelingrenal insufficiency

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