Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

386
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
386
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

522
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
522
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

943
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
943
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

701
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
701

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-Based Outcomes Following Fenestrated Endovascular Aortic Repair With the Anaconda Stent Graft.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same author

Effect of breed and sex on carcass traits, meat quality and fatty acid composition of young cattle formed based on animal protein production and qualified meat in plateau condition.

Archives animal breeding·2026
Same author

Safety and effectiveness of ETHIZIA versus TachoSil for hemostasis during open liver surgery: a randomized controlled multicenter trial.

HPB : the official journal of the International Hepato Pancreato Biliary Association·2026
Same author

Spontaneous Myocardial Infarction After Left Main Revascularization: The EXCEL Trial.

Circulation·2026
Same author

Electrosurgical Laceration and Stabilization of Clip Followed by Transapical Mitral Valve Replacement after Failed Transcatheter Edge-to-Edge Mitral Valve Repair: A Promising Alternative to Surgery.

Interdisciplinary cardiovascular and thoracic surgery·2025
Same author

Editorial: Do less, do better? Challenging the concomitant PCI paradigm in TAVR.

Cardiovascular revascularization medicine : including molecular interventions·2025

Related Experiment Video

Updated: Mar 3, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K

Mechanical versus bioprosthetic aortic valve replacement.

Stuart J Head1, Mevlüt Çelik1, A Pieter Kappetein1

  • 1Department of Cardiothoracic Surgery, Erasmus University Medical Centre, Dr Molewaterplein 40, 3015 GE Rotterdam, The Netherlands.

European Heart Journal
|April 27, 2017
PubMed
Summary

Mechanical valves carry bleeding risks, while bioprosthetic valves risk deterioration. Current evidence suggests mechanical valves may offer better outcomes, especially for younger patients needing aortic valve replacement.

Keywords:
AnticoagulationAortic valve replacementBiologicalBioprosthesisBioprostheticHeart valveMechanicalReviewSuturelessTissueTissue engineered heart valveTranscatheter aortic valve implantation

More Related Videos

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.5K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K

Related Experiment Videos

Last Updated: Mar 3, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.9K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

3.5K
Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

14.3K

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Clinical Medicine

Background:

  • Mechanical valves for aortic valve replacement (AVR) pose bleeding risks due to anticoagulation.
  • Bioprosthetic valves risk structural deterioration and reoperation.
  • Current guidelines recommend mechanical valves for patients under 60.

Purpose of the Study:

  • To compare outcomes of mechanical versus bioprosthetic valves in aortic valve replacement.
  • To evaluate the current trend of increased bioprosthetic valve use across age groups.
  • To inform clinical decision-making regarding valve choice in valvular heart disease.

Main Methods:

  • Systematic review of studies using propensity-matching or multivariable analysis.
  • Comparison of outcomes between mechanical and bioprosthetic valve recipients.
  • Analysis of trends in bioprosthetic valve implantation over recent decades.

Main Results:

  • Studies found similar outcomes or favorable outcomes with mechanical prostheses, particularly in younger patients.
  • Despite guidelines, bioprosthetic valve use has increased significantly in all age groups.
  • No current evidence supports lowering the age threshold for bioprosthetic valve implantation.

Conclusions:

  • The risk/benefit ratio of mechanical versus bioprosthetic valves requires careful consideration.
  • Advancements in valve design and procedures may impact future valve choice.
  • Caution is advised regarding increased bioprosthetic valve use in middle-aged patients without proven benefit.