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Updated: Mar 3, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Left bundle branch block: from cardiac mechanics to clinical and diagnostic challenges

Elena Surkova1,2, Luigi P Badano1, Roberto Bellu1,3

  • 1Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|April 27, 2017
PubMed

Insights

Left bundle branch block (LBBB) alters left ventricular (LV) function, leading to cardiac remodeling. Advanced imaging aids in assessing LBBB

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Medical Imaging

Background:

  • Left bundle branch block (LBBB) significantly alters left ventricular (LV) activation, mechanics, and perfusion.
  • These changes can lead to pathological cardiac remodeling and impact patient outcomes.
  • Understanding LBBB has evolved from an electrocardiographic pattern to a critical clinical finding.

Purpose of the Study:

  • To review current data on LBBB epidemiology, diagnosis, and clinical impact.
  • To explore the role of advanced imaging in assessing LBBB-related cardiac dysfunction.
  • To discuss the implications of imaging findings for diagnostic and treatment strategies.

Main Methods:

  • Comprehensive literature review of studies on LBBB.
  • Analysis of data on LBBB epidemiology, diagnosis, and prognosis.
  • Evaluation of the utility of various cardiac imaging modalities (e.g., echocardiography, cardiac MRI, nuclear imaging) in LBBB patients.

Main Results:

  • LBBB is associated with significant alterations in LV mechanics and perfusion.
  • Imaging techniques provide crucial insights into the pathophysiological mechanisms of LV remodeling in LBBB.
  • These insights can refine diagnostic and therapeutic approaches.

Conclusions:

  • LBBB is a critical finding with substantial impact on cardiac function and patient prognosis.
  • Advanced cardiac imaging plays a vital role in assessing LBBB-induced abnormalities.
  • Integrating imaging data can optimize the management and treatment strategies for patients with LBBB.

Keywords:
Cardiovascular imagingElectrocardiographyLeft bundle branch blockLeft ventricular remodellingPrognosis

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