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Acquired cystic kidney disease: an under-recognized condition in children with end-stage renal disease

Eugene Y H Chan1, Bradley A Warady2

  • 1Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA.

Pediatric Nephrology (Berlin, Germany)
|April 27, 2017
PubMed

Insights

Acquired cystic kidney disease (ACKD) affects patients with end-stage renal disease (ESRD). Surveillance is recommended due to potential complications like renal cell carcinoma.

Area of Science:

  • Nephrology
  • Oncology
  • Pediatric Nephrology

Background:

  • Acquired cystic kidney disease (ACKD) is prevalent in end-stage renal disease (ESRD) patients.
  • ACKD involves small kidneys with multiple cysts, distinct from hereditary forms.
  • Pediatric data indicate a high ACKD incidence (21.6-45.8%) in children on dialysis.

Observation:

  • ACKD incidence correlates with longer dialysis duration in children.
  • Pathogenesis involves proto-oncogene activation.
  • Most ACKD cases are asymptomatic.

Findings:

  • High incidence of ACKD in pediatric dialysis patients mirrors adult rates.
  • Proto-oncogene activation is a key factor in ACKD development.
  • Renal cell carcinoma is a significant complication of ACKD.

Implications:

  • Routine surveillance for ACKD is crucial in at-risk populations.
  • Understanding ACKD pathogenesis may lead to targeted therapies.
  • Early detection of ACKD complications can improve patient outcomes.

Keywords:
Acquired cystic kidney diseaseAcquired cystic renal diseaseChildrenChronic kidney diseaseEnd stage renal diseaseRenal cell carcinoma

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