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Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.0K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
782
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.3K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.3K
Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

586
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
586
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.0K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.0K
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

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In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
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Related Experiment Video

Updated: Mar 3, 2026

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

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Biodegradable Stents for Caustic Esophageal Strictures: Do They Work?

Rakesh Kochhar1, Jayanta Samanta2, Jahangeer Basha2

  • 1Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. dr_kochhar@hotmail.com.

Dysphagia
|April 27, 2017
PubMed
Summary

Biodegradable stents show limited efficacy for refractory caustic esophageal strictures. Long-term relief is inadequate due to insufficient radial force, often requiring ongoing dilatations or surgery.

Keywords:
Biodegradable stentsCaustic stricturesDeglutition disorderDilatationDysphagiaEsophageal stricturesRefractory esophageal strictures

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ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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Area of Science:

  • Gastroenterology
  • Medical Devices
  • Surgical Innovation

Background:

  • Biodegradable (BD) stents are used for esophageal strictures (ES).
  • Limited data exists on their efficacy in caustic-induced ES.
  • Refractory cases present a significant management challenge.

Purpose of the Study:

  • To evaluate the efficacy of biodegradable stents in treating refractory caustic-induced esophageal strictures.
  • To assess the long-term outcomes and complications associated with BD stent use in this patient population.

Main Methods:

  • Retrospective multi-center study involving 13 adult patients.
  • Patients with refractory caustic-induced ES underwent BD stent placement.
  • Follow-up included immediate complications and long-term outcomes over 3 years.

Main Results:

  • Successful BD stent placement in all patients; complications included chest pain and migration.
  • High rates of restenosis and dysphagia recurrence at 3, 6, and 12 months (69.2%, 77%, and 77% respectively).
  • Significant need for ongoing dilatations (monthly to quarterly) and surgery (23% over 3 years).

Conclusions:

  • Biodegradable stents have limited efficacy for refractory caustic-induced esophageal strictures.
  • Current BD stents lack adequate short-term radial force for sustained relief.
  • Alternative or adjunctive treatments may be necessary for long-term management.