Current MitraClip experience, safety and feasibility in the Netherlands

Area of Science:

• Cardiovascular Medicine
• Interventional Cardiology
• Medical Device Technology

Background:

• Limited data exists on the MitraClip procedure's safety and efficacy within the Netherlands.
• Understanding the Dutch experience is crucial for optimizing transcatheter mitral valve repair strategies.

Purpose of the Study:

• To provide a comprehensive overview of the MitraClip procedural experience in the Netherlands.
• To assess the safety, efficacy, and trends of MitraClip implantation in a national cohort.

Main Methods:

• A pooled analysis of anonymized data from 1151 consecutive MitraClip patients across 13 Dutch hospitals.
• Data collection involved product specialists and local operators, with intra-procedural assessment of mitral regurgitation via transesophageal echocardiography.
• Technical and device success were evaluated using modified Mitral Valve Academic Research Consortium (MVARC) definitions.

Main Results:

• The study included patients with a median age of 76 years, predominantly male (59%), with moderate or severe mitral regurgitation, primarily functional (72%).
• Device success (91%) and technical success (95%) rates were high and consistent over time. Significant reduction in mitral regurgitation was achieved in 94% of patients.
• The use of multiple clips (≥2) increased from 22% in 2009 to 52% in 2016, while device time decreased from 145 to 55 minutes.

Conclusions:

• The MitraClip experience in the Netherlands is expanding, demonstrating excellent technical and device success rates.
• Trends indicate improved procedural efficiency, with reduced device times and a growing preference for multiple clip applications.
• The MitraClip is an effective treatment option for mitral regurgitation in the Dutch patient population.