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Updated: Mar 3, 2026

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
Published on: August 1, 2018
Dual In-Tether Chiral Centers Modulate Peptide Helicity
Kuan Hu1, Chengjie Sun1, Mengying Yu1
1School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School , Shenzhen, Guangdong 518055, China.
Abstract:
The facile chemical modification on the peptide cross-linking moiety is an important strategy for improving the physicochemical properties of a peptide. Herein, peptides were constrained into helical conformations via the synergistic effects of dual in-tether chiral centers. A pentapeptide minimalistic model was used to determine the correlation between the absolute configurations of the dual in-tether chiral centers and the secondary structures of the peptides. This strategy provides an on-tether modification site that does not interrupt the secondary structure of the peptide.
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