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Updated: Mar 3, 2026
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An Approach to the Core of Lactonamycin
Philip J Parsons1, Daniel R Jones1, Lee J Walsh1
1Department of Chemistry, Imperial College London , South Kensington, London SW7 2AZ, U.K.
Abstract:
A cascade reaction has been developed for the synthesis of lactonamycin. In this paper, we demonstrate that a transition-metal-free thermal ene-diyne cyclization can be used for the construction of the entire core of the antibiotic lactonamycin and anticancer agent lactonamycin Z.
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