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Relationship between the abnormal diastolic vortex structure and impaired left ventricle filling in patients with

Bin-Yu Zhou1, Ming-Xing Xie, Jing Wang

  • 1Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Department of Ultrasound, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China.

Medicine
|April 27, 2017
PubMed

Insights

Hyperthyroidism alters left ventricular (LV) diastolic vortex dynamics, impacting cardiac function. Vector flow mapping reveals changes in vortex strength and pressure gradients, correlating with LV filling and thyroid hormone levels.

Area of Science:

  • Cardiology
  • Biophysics
  • Medical Imaging

Background:

  • Intraventricular hydrodynamics are crucial for cardiac function assessment.
  • The relationship between diastolic vortex and left ventricular (LV) filling requires further elucidation.

Purpose of the Study:

  • To evaluate the evolution of LV diastolic vortex in hyperthyroidism (HT).
  • To explore alterations in hydromechanical characteristics using sensitive indexes in HT patients.

Main Methods:

  • Utilized offline vector flow mapping (VFM) to analyze LV diastolic blood flow and fluid dynamics.
  • Calculated hemodynamic parameters, vortex area (A), circulation (C), and intraventricular pressure gradient (ΔP) across diastolic phases.

Main Results:

  • Patients with thyrotoxic cardiomyopathy (HT2) showed lower E/A ratio and LVEF, and larger left atrium diameter (LAD).
  • Early/mid-diastole vortex and pressure gradients were elevated in simple hyperthyroidism (HT1) but reduced in HT2 compared to controls.
  • Late diastole showed increased vortex and pressure gradients in HT2 versus controls.
  • Correlations found between circulation (C) and E/A, vortex strength (M) and pressure gradient (ΔPM), and circulation (L) and free T3 (FT3).

Conclusions:

  • VFM is effective in detecting the relationship between LV diastolic vortex changes and abnormal LV filling.
  • Hyperthyroidism significantly alters intraventricular hydrodynamics, with distinct patterns in simple HT versus thyrotoxic cardiomyopathy.

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