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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Protein Digestion01:02

Protein Digestion

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Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
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The Proteasome Structure01:17

The Proteasome Structure

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The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
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Transducer Mechanism: Enzyme-Linked Receptors01:27

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Role of Proteins in the Human Body01:28

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Proteins are the building block of life. They are also  the most abundant macromolecules with as many diverse roles in the body. They are part of many structural components that provide unique shapes and structures to animal cells, tissues, and organs. In addition, they also act as biological catalysts and carry out several anabolic and catabolic reactions. Notably, some proteins are chemical messengers and regulate many critical processes, such as metabolism, growth, and development. They...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Bioactive Peptides.

Eric Banan-Mwine Daliri1, Deog H Oh2, Byong H Lee3,4

  • 1Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Korea. ericdaliri@yahoo.com.

Foods (Basel, Switzerland)
|April 27, 2017
PubMed
Summary

Consumers seek functional foods for health benefits. Food-derived bioactive peptides show promise, but industrial production and clinical validation face challenges for widespread use.

Keywords:
antihypertensive peptidesbioactivitycytotoxicityfunctional foods

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Area of Science:

  • Food Science
  • Biochemistry
  • Nutraceuticals

Background:

  • Growing consumer demand for functional foods and nutraceuticals drives market growth.
  • Bioactive peptides, derived from food, are recognized for their health-promoting properties due to high tissue affinity and specificity.
  • Research into food-derived bioactive peptides has surged, with numerous candidates identified.

Purpose of the Study:

  • To review the current understanding of health effects associated with food-derived bioactive peptides.
  • To discuss established processing methods for these peptides.
  • To identify and analyze the challenges hindering their industrial development and application.

Main Methods:

  • Literature review of scientific publications on food-derived bioactive peptides.
  • Analysis of existing research on peptide bioactivity, processing, and health claims.
  • Identification of key challenges in industrial scale-up and clinical validation.

Main Results:

  • Numerous food-derived bioactive peptides with potential health benefits have been identified.
  • Significant obstacles remain, including optimizing industrial-scale production and conducting rigorous clinical trials.
  • Factors like allergenicity, cytotoxicity, and gastrointestinal stability require thorough investigation.

Conclusions:

  • Food-derived bioactive peptides offer significant therapeutic potential but require further research and development.
  • Addressing challenges in production, validation, and safety is crucial for realizing their market potential.
  • Continued investigation into processing and stability is essential for effective application.