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Updated: Mar 3, 2026
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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
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The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design
Christina Beatrice Karsten1, Galit Alter1
1Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
Cell Reports
|April 27, 2017
Abstract:
Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.
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