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Marrow uptake of galactosyl-containing neoglycoproteins: implications in stem cell homing
1Veterans Administration Medical Center, Jackson, Mississippi 39216.
Experimental Hematology
|October 1, 1988
Abstract:
Tissue distribution of synthetic neoglycoproteins was studied after intravenous injection of 125I-labeled galactosyl-, mannosyl- and fucosyl-BSA. The highest uptake of all three reagents occurred in the bone marrow. Spleen also took up considerable proportions of galactosyl and mannosyl reagents, while liver only took up galactosyl-BSA. Implication of these findings in the recognition and homing of intravenously transplanted hemopoietic cells to bone marrow is discussed.