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Published on: May 8, 2017
Expression of MMP-13 in human temporomandibular joint disc derangement and osteoarthritis
Juliano Henrique Perotto1, Flavio de Alcantara Camejo1, Andrea Duarte Doetzer1
1a School of Health and Biosciences , Pontifícia Universidade Católica do Paraná (PUCPR) , Curitiba , Brazil.
Objective:
MMP-13 performs digestion of collagen, which is a primary component of the temporomandibular joint (TMJ) articular disc. This study evaluated the expression of MMP-13 in patients with anterior disc displacement with (ADDwR) and without reduction (ADDwoR), and in the presence of TMJ osteoarthrosis.
Methods:
Thirty-nine human temporomandibular joint disc samples were collected and divided in two ways: ADDwR (21 samples), ADDwoR (10 samples), and a control group (8 samples); and with osteoarthrosis (10 samples) and without osteoarthrosis (29 samples). Immunostaining of the TMJ discs was statistically compared between the groups.
Results:
There was no statistically significant difference for the area of MMP-13 immunostaining between the control group, ADDwR, and ADDwoR, nor between groups with and without osteoarthrosis.
Conclusion:
This study suggests MMP-13 is not significantly involved in collagen degradation in human TMJ disc displacement or osteoarthrosis.
