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Updated: Mar 3, 2026
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Spontaneous migraine attack causes alterations in default mode network connectivity: a resting-state fMRI case report
Andrea Edit Edes1,2,3, Lajos Rudolf Kozak4,5, Mate Magyar4,6
1MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Nagyvárad Square 4, Budapest, H-1089, Hungary. edes.andrea@pharma.semmelweis-univ.hu.
Migraine attacks involve altered default mode network (DMN) connectivity. This study suggests DMN functional connectivity changes may serve as a migraine biomarker.
Area of Science:
- Neuroimaging
- Neurology
- Functional Connectivity
Background:
- Migraine pathophysiology lacks a definitive neuroimaging biomarker.
- Resting-state functional connectivity (rs-FC) during headache is incompletely understood.
Observation:
- A case study examined rs-FC in a migraine patient during spontaneous attack vs. interictal phase.
- Default Mode Network (DMN) connectivity was analyzed using resting-state functional MRI.
Findings:
- Decreased intrinsic DMN connectivity observed, except in pain interpretation areas.
- Increased connectivity between DMN and migraine-related regions (pons, hypothalamus) during attacks.
Implications:
- Altered DMN connectivity during migraine headaches suggests maladaptive top-down pain modulation.
- These functional connectivity changes may represent a specific biomarker for migraine.
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