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Updated: Mar 3, 2026
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
Published on: November 10, 2023
[Correlation between Bone Marrow Fibrous Proliferation and Prognosis of Acute Myeloid Leukemia]
Bin Zhu1, Shao-Ying Pan1, Zhi-Yong Ding1
1Department of Hematology, Shanghai Fengxian District Central Hospital, Shanghai 201499,China.
Objective:
To investigate the correlation between the bone marrow fibrous proliferation and the prognosis of acute myeloid leukemia(AML).
Methods:
The quantitative method was used to analyze the reticulin fiber density (RFD) of AML patients. the bone marrow sections from 39 primary AML patients and 35 normal controls were collected to compare the RFD between these 2 groups. The prognosis value of RFD for AML were estimated by using appropriate statistical analysis.
Results:
RFD in primary AML was significantly higher than that in normal controls(2.41%±0.23% vs 1.14%±0.06%)(P<0.05). Relapse-free survival(RFS) analysis showed that the patients with RFD more than 1.68% indicated poor RFS, and the overall survival(OS) analysis showed that patients with RFD more than 2.66% indicated poor overall survival (P<0.05). Besides, there were no relationship between RFD and the BM blast count (r=0.01) and WBC counts (r=0.04) at diagnosis(P>0.05).
Conclusion:
The RFD in bone marrow is a high risk factor in poor prognosis of AML patients.
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