Testing a Computerized Cognitive Training Protocol in Adults Aging With HIV-Associated Neurocognitive Disorders:...

Area of Science:

• Neurology
• Gerontology
• Infectious Diseases

Background:

• Nearly 50% of adults with HIV experience neurocognitive disorders, impacting daily functioning.
• These disorders, known as HIV-associated neurocognitive disorders (HAND), may worsen with age.
• Cognitive interventions are crucial for managing HAND and improving quality of life in aging individuals with HIV.

Purpose of the Study:

• To investigate the rationale and development of a computerized speed of processing training program for adults aging with HIV.
• To assess the program's potential to improve cognitive abilities, daily functioning, and quality of life.
• To establish the efficacy of this intervention in a population with a high prevalence of HAND.

Main Methods:

• A longitudinal randomized controlled trial (RCT) design is employed.
• The study includes examination of intervention rationale, study design, eligibility criteria, HAND assessment, intervention dosage, assessment battery, and biomarkers.
• Enrollment is ongoing for the trial registered as NCT02758093.

Main Results:

• The project was funded in April 2016, and participant enrollment is currently underway.
• Initial results are anticipated for publication in 2020.
• The study aims to provide the first efficacy data for speed of processing training in adults with HIV.

Conclusions:

• Novel cognitive interventions may benefit individuals with HAND.
• The current RCT protocol provides a framework for evaluating the therapeutic efficacy of such interventions.
• Further research is needed to explore and validate new cognitive approaches for managing HAND.