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Do guidelines for treating chest disease in children use Cochrane Reviews effectively? A systematic review

Andrew P Prayle1, Tessy Cox1, Sherie J Smith1

  • 1Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK.

Thorax
|April 28, 2017
PubMed

Insights

UK paediatric respiratory guidelines often fail to cite or align with Cochrane Reviews, the best evidence. This suggests potential gaps in evidence-based practice for child respiratory care.

Area of Science:

  • Evidence-based medicine
  • Clinical practice guidelines
  • Systematic reviews

Background:

  • Cochrane Reviews represent a high standard of evidence synthesis.
  • UK guidelines for paediatric respiratory disease were examined for Cochrane Review integration.
  • The study aimed to assess the utilization and concordance of Cochrane Reviews in these guidelines.

Discussion:

  • A significant proportion (40%) of recommendations that could be informed by Cochrane Reviews did not cite them.
  • A notable percentage (26%) of guideline recommendations were not fully aligned with the findings of linked Cochrane Reviews.
  • This indicates a potential disconnect between synthesized evidence and clinical guideline development.

Key Insights:

  • 40% of relevant Cochrane Reviews were not cited in UK paediatric respiratory guidelines.
  • 26% of guideline recommendations diverged from Cochrane Review conclusions.
  • Potential underutilization and misapplication of high-quality evidence in paediatric respiratory care.

Outlook:

  • Improving the integration of Cochrane Reviews into guideline development is crucial.
  • Further investigation into reasons for non-citation and disagreement is warranted.
  • Enhancing evidence-based practice in paediatric respiratory medicine requires addressing these identified gaps.

Keywords:
Asthma GuidelinesPaediatric Lung Disaese

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