Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Operation, anesthesia, and the endorphin system.

D B Carr1, M T Murphy

  • 1Analgesic Peptide Research Unit, Massachusetts General Hospital, Boston 02114.

International Anesthesiology Clinics
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cosmology and fundamental physics with the ELT-ANDES spectrograph.

Experimental astronomy·2024
Same author

Association between hamstring coactivation during isokinetic quadriceps strength testing and knee cartilage worsening over 24 months.

Osteoarthritis and cartilage·2022
Same author

Clinical value of weight-bearing CT and radiographs for detecting patellofemoral cartilage visualized by MRI in the MOST study.

Osteoarthritis and cartilage·2021
Same author

Nifedipine maintenance tocolysis and perinatal outcome: an individual participant data meta-analysis.

BJOG : an international journal of obstetrics and gynaecology·2016
Same author

A patient's recollection of pre-operative status is not accurate one year after arthroplasty of the hip or knee.

The bone & joint journal·2015
Same author

Constraint on a varying proton-electron mass ratio 1.5 billion years after the big bang.

Physical review letters·2015
Same journal

Regional Anesthesia for Hip Fracture Surgery in Frail Adults: Primary Anesthetic and Perioperative Analgesic Approaches.

International anesthesiology clinics·2026
Same journal

The Transition of Total Joint Arthroplasty From Inpatient to Ambulatory Surgery Centers: Evolution, Evidence, and Implications.

International anesthesiology clinics·2026
Same journal

Patient Blood Management in Orthopedic Surgery.

International anesthesiology clinics·2026
Same journal

The Practitioner's Guide to Upper Extremity Nerve Blocks.

International anesthesiology clinics·2026
Same journal

Anesthetic Challenges and Strategies in Pediatric Spine Surgery.

International anesthesiology clinics·2026
Same journal

Development of a Preoperative Physical Frailty-associated Screening Process: A Quality Improvement Initiative.

International anesthesiology clinics·2026
See all related articles

The endogenous opioid system, including endorphins, becomes active during stress to buffer bodily responses. This system

Area of Science:

  • Neuroscience
  • Endocrinology
  • Immunology

Background:

  • Endogenous opioid peptides are crucial regulators of neuronal pathways and extraneural targets like white blood cells.
  • The opioid system, typically quiescent, activates during stress to modulate hormonal secretion and biological effects.
  • Opioid peptides act centrally and peripherally to integrate and buffer bodily responses to various stressors.

Purpose of the Study:

  • To elucidate the complex roles of endogenous opioid peptides and their receptors.
  • To understand the functional heterogeneity within the opioid system.
  • To explore the potential of opioid system knowledge in developing novel therapeutics.

Main Methods:

  • Review of existing literature on opioid peptide function.

Related Experiment Videos

  • Analysis of studies detailing opioid receptor interactions.
  • Investigation into the physiological effects of opioid peptides during stress.

    • Main Results:

    • Endogenous opioid peptides modulate numerous neuronal and extraneural targets.
    • The opioid system actively buffers sympathetic responses like tachycardia and vasoconstriction during stress.
    • Opiates administered to resting subjects can paradoxically induce stress-like responses.

    Conclusions:

    • The opioid system exhibits remarkable functional heterogeneity and detail.
    • Understanding individual opioid peptide and receptor roles is key to future research.
    • Exploiting this knowledge offers significant potential for next-generation therapeutic development.