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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.7K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.7K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.5K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.5K
Determination01:51

Determination

21.2K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.2K
Gastrulation01:56

Gastrulation

68.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.2K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.3K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K

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Related Experiment Video

Updated: Mar 3, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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New Lncs to mesendoderm specification.

Michael Alexanian1, Thierry Pedrazzini1, Samir Ounzain1

  • 1Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland.

Journal of Thoracic Disease
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) play crucial roles in mammalian development. This review summarizes recent advances in understanding lncRNA functions during mesendoderm specification and primitive streak formation.

Keywords:
Long noncoding RNAs (lncRNAs)

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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
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Area of Science:

  • Genomics
  • Developmental Biology
  • RNA Biology

Background:

  • Mammalian genomes are extensively transcribed, producing numerous long noncoding RNAs (lncRNAs).
  • lncRNAs are increasingly recognized for their regulatory functions, particularly during embryonic development.
  • Many lncRNAs show specific expression patterns and are involved in regulating key developmental genes.

Purpose of the Study:

  • To review and summarize recent findings on the roles of lncRNAs in mesendoderm specification.
  • To highlight the involvement of lncRNAs in gastrulation and primitive streak formation.

Main Methods:

  • Literature review of recent advances in lncRNA research.
  • Focus on studies investigating lncRNA function during early mammalian development.

Main Results:

  • lncRNAs are critical regulators of mesendoderm (ME) specification.
  • Specific lncRNAs are involved in the formation of the primitive streak (PS).
  • lncRNAs influence the regulation of key developmental factors during gastrulation.

Conclusions:

  • lncRNAs are essential components of the regulatory networks governing early mammalian development.
  • Further research into lncRNA function will illuminate mechanisms of gastrulation and developmental disorders.