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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
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Comparative genomics of human stem cell factor (SCF).

Moein Dehbashi1, Elahe Kamali1, Sadeq Vallian1

  • 1Genetics Division, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.

Molecular Biology Research Communications
|April 28, 2017
PubMed
Summary

Stem cell factor (SCF) gene analysis reveals close evolutionary links between humans and chimpanzees. This research highlights genetic similarities and gene flow in SCF among humans, Neanderthals, and chimpanzees, suggesting shared ancestry.

Keywords:
ChimpanzeeComparative genomicsNeanderthalStem cell factor

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Area of Science:

  • Evolutionary Biology
  • Genetics
  • Bioinformatics

Background:

  • Stem cell factor (SCF) is a crucial protein involved in vital cellular processes like hematopoiesis, gametogenesis, and melanogenesis.
  • Understanding the evolutionary conservation and genetic variations of SCF is important for comprehending human and primate evolution.

Purpose of the Study:

  • To perform a comparative analysis of stem cell factor (SCF) nucleotide sequences in humanoids.
  • To investigate the evolutionary relationships and genetic similarities of SCF across different hominoid species using bioinformatics.

Main Methods:

  • Utilized bioinformatics tools including NCBI-BLAST, MEGA6, and JBrowse for nucleotide sequence analysis.
  • Performed comparative sequence analysis to identify evolutionary relationships and gene copy numbers.

Main Results:

  • NCBI-BLAST and MEGA6 analyses clustered humans and chimpanzees (Pan troglodytes) together, indicating high nucleotide sequence similarity for SCF.
  • JBrowse analysis revealed that Neanderthal SCF has a single copy number, similar to modern humans, with partially conserved nucleotide sequences.
  • Confirmed gene flow and genetic similarity of the SCF gene among humans, chimpanzees, and Neanderthals.

Conclusions:

  • The SCF gene exhibits significant genetic similarity and evidence of gene flow between humans and chimpanzees, suggesting a shared evolutionary past.
  • The findings support the hypothesis that the SCF gene was transferred, partly intact in sequence or function, from common ancestors to Neanderthals and subsequently to modern humans.