Related Experiment Video
Updated: Mar 3, 2026
04:41
Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
Published on: March 10, 2023
1.7K
Liver resection for hepatocellular carcinoma ≥5 cm
Giuseppe Maria Ettorre1, Giovanni Battista Levi Sandri1, Marco Colasanti1
1Division of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Lazio, Italy.
Translational Gastroenterology and Hepatology
|April 28, 2017
Summary
Surgical resection of hepatocellular carcinoma (HCC) is feasible for tumors larger than 10 cm. This study found no significant difference in post-operative morbidity between patients with HCC between 5-10 cm and those with HCC ≥10 cm.
Area of Science:
- Hepatobiliary Surgery
- Surgical Oncology
- Gastroenterology
Background:
- Management of large hepatocellular carcinoma (HCC) >5 cm remains controversial.
- Surgical resection is a primary treatment for HCC, but tumor size can influence outcomes.
Purpose of the Study:
- To compare morbidity and mortality after surgical resection of HCC based on tumor size.
- To evaluate the safety and efficacy of resecting large HCC tumors (≥10 cm).
Main Methods:
- Retrospective analysis of 429 liver resections for HCC performed between 2001 and present.
- Patients were divided into two groups: Group 1 (HCC 5-10 cm, n=88) and Group 2 (HCC ≥10 cm, n=39).
- Comparison of operative details, post-operative complications, and hospital stay between the two groups.
Main Results:
- Major liver resections were more frequent in Group 2 (66.6%) vs. Group 1 (36.3%) (P=0.001).
- Median operative time was significantly longer in Group 2 (P=0.001).
- Post-operative morbidity (P=0.595) and hospital stay (P=0.897) were similar between the groups.
Conclusions:
- Tumor size alone does not contraindicate surgical resection for HCC.
- Hepatocellular carcinoma ≥10 cm can be safely resected with comparable morbidity to smaller tumors.
