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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Biological Clocks and Seasonal Responses02:45

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Updated: Mar 3, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian clocks, diets and aging.

Amol Chaudhari1, Richa Gupta1, Kuldeep Makwana1

  • 1Department of Biological, Geological, and Environmental Sciences and Center for Gene Regulation in Health and Diseases, Cleveland State University, Cleveland, OH, USA.

Nutrition and Healthy Aging
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

Dietary intake influences health and longevity, with calorie restriction showing metabolic benefits. Circadian clocks are key to these effects, linking feeding patterns to metabolism and lifespan.

Keywords:
Biological rhythms and clockscell signalingfood anticipationtranscription

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Area of Science:

  • Chronobiology and Nutritional Science
  • Metabolic Regulation and Longevity

Background:

  • Dietary regimens significantly impact physiological systems, influencing pathologies like cardiovascular and metabolic diseases.
  • Calorie restriction (CR) is a dietary paradigm with documented metabolic benefits and lifespan-extending potential.
  • Circadian clocks, responsible for biological rhythms, are increasingly recognized as integral to CR mechanisms.

Purpose of the Study:

  • To explore the intricate interplay between circadian clocks and dietary paradigms.
  • To elucidate how nutrient-regulated circadian clocks and clock-regulated nutrient pathways contribute to CR's benefits.
  • To assess the potential of the circadian system for future medical applications in metabolism and longevity.

Main Methods:

  • Review of recent scientific literature on circadian biology and dietary interventions.
  • Analysis of studies investigating the bidirectional regulation between feeding/nutrients and circadian clocks.
  • Examination of research linking circadian disruption to reduced fitness and lifespan.

Main Results:

  • Circadian clocks are integral to the metabolic effects of calorie restriction.
  • Nutrient intake regulates circadian clock function, impacting physiological rhythms.
  • Circadian clocks modulate nutrient signaling pathways, contributing to metabolic health.

Conclusions:

  • The interaction between circadian clocks and dietary patterns, particularly CR, underlies significant metabolic benefits and longevity.
  • Understanding this interplay is crucial for harnessing the circadian system for therapeutic interventions.
  • Future research should focus on leveraging circadian biology for medical applications related to metabolic syndrome and aging.