Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

6.7K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
6.7K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

16.2K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
16.2K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

9.9K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
9.9K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

3.5K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
3.5K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

5.5K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.5K
Classification of Epithelial Tissues: Overview01:22

Classification of Epithelial Tissues: Overview

26.1K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
26.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.

Cell death & disease·2024
Same author

Phase II trial of galiximab (anti-CD80 monoclonal antibody) plus rituximab (CALGB 50402): Follicular Lymphoma International Prognostic Index (FLIPI) score is predictive of upfront immunotherapy responsiveness.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same author

A phase II trial of lenalidomide plus rituximab in previously untreated follicular non-Hodgkin's lymphoma (NHL): CALGB 50803 (Alliance).

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Concordant bone marrow involvement of diffuse large B-cell lymphoma represents a distinct clinical and biological entity in the era of immunotherapy.

Leukemia·2017
Same author

Assessment of semi-quantitative grading of red blood cell abnormalities utilizing images from the CellaVision DM96 compared to manual light microscopy.

International journal of laboratory hematology·2017
Same author

Clinicopathologic and molecular characterization of myeloid neoplasms with isolated t(6;9)(p23;q34).

International journal of laboratory hematology·2017
Same journal

Pilot-Scale Evaluation of Partial-Slide Imaging for Detecting Critical Morphological Features (Excluding Parasites): Initial UK Implementation of a Hybrid Virtual-Light Microscopy Model in Haematology.

International journal of laboratory hematology·2026
Same journal

Testing for Non-Severe Heritable Platelet Function Disorders.

International journal of laboratory hematology·2026
Same journal

Thrombocytopenia in Pregnancy: A 5-Year Analysis of Characteristics and Practices From a Tertiary Academic Center.

International journal of laboratory hematology·2026
Same journal

AI In Leukemia Diagnostics: Complementing the Pathologist's Role.

International journal of laboratory hematology·2026
Same journal

Advanced Molecular Analysis in Hemophilia A in a Single Step: Next Generation Sequencing (NGS) and Copy Number Variation (CNV) Analysis.

International journal of laboratory hematology·2026
Same journal

Overwhelming Post-Splenectomy Sepsis From Capnocytophaga canimorsus.

International journal of laboratory hematology·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning
08:58

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning

Published on: November 19, 2018

13.2K

2016 WHO Classification update-What's new in lymphoid neoplasms.

E D Hsi1

  • 1Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

International Journal of Laboratory Hematology
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

The World Health Organization (WHO) classification of lymphoid tumors has been updated due to significant advances in molecular genetics and biology. This overview highlights key changes in hematologic malignancies since the 2008 edition.

Keywords:
World Health Organizationclassificationlymphoma

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

20.6K
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

828

Related Experiment Videos

Last Updated: Mar 3, 2026

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning
08:58

Label-Free Identification of Lymphocyte Subtypes Using Three-Dimensional Quantitative Phase Imaging and Machine Learning

Published on: November 19, 2018

13.2K
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

20.6K
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

828

Area of Science:

  • Hematopathology
  • Oncology
  • Molecular Genetics

Background:

  • The 4th edition of the WHO Classification of Hematopoietic and Lymphoid Tumours was published in 2008.
  • Significant advancements in molecular genetics, biology, and clinical behavior of hematologic malignancies have occurred since 2008.
  • Existing classification models require updates to reflect new scientific understanding.

Purpose of the Study:

  • To provide an overview of important changes and updates to lymphoid tumors.
  • To highlight advancements in the understanding of hematologic malignancies.
  • To prepare for the upcoming 5th edition of the WHO Classification of Hematopoietic and Lymphoid Tumours.

Main Methods:

  • Review of recent scientific literature and molecular data.
  • Analysis of advancements in the understanding of lymphoid neoplasms.
  • Synthesis of new findings relevant to the WHO classification system.

Main Results:

  • Accumulation of substantial new knowledge regarding the molecular genetics and biology of lymphoid tumors.
  • Evolution of concepts and models in hematologic malignancy classification.
  • Identification of necessary updates for the next WHO classification edition.

Conclusions:

  • The field of hematopathology necessitates frequent updates to tumor classifications.
  • New molecular and biological insights are crucial for refining the diagnosis and understanding of lymphoid neoplasms.
  • This overview serves as a precursor to the formal 5th edition WHO Classification.