Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preformulation studies of levonorgestrel: A supplier variation analysis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026

Same author

Predicting Agitation Stability of Monoclonal Antibodies during Developability Assessment.

Molecular pharmaceutics·2026

Same author

Exploring Digestion-Induced Fed-State Simulated Intestinal Media with a Lipid Fraction and Compositional Variability.

The AAPS journal·2026

Same author

Computational modeling of the early-stage solubilization of a fenofibrate aggregate into mixed bile salt and fatty acids micelles.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026

Same author

Indirect effects of pH on drug solubility in fed state simulated intestinal fluids.

International journal of pharmaceutics·2026

Same author

Drug Solubilization in Simulated Intestinal Fluids vs Lipophilicity: Does Charge Matter?

Molecular pharmaceutics·2026

Same journal

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026

Same journal

PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.

Nature communications·2026

Same journal

Transient distortions of the South Atlantic Anomaly radiation environments driven by electric fields.

Nature communications·2026

Same journal

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase.

Nature communications·2026

Same journal

Structural and mechanistic insights into primer synthesis initiation by DNA primase.

Nature communications·2026

Same journal

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 3, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Efficient self-emulsification via cooling-heating cycles.

Slavka Tcholakova¹, Zhulieta Valkova¹, Diana Cholakova¹

¹Department of Chemical and Pharmaceutical Engineering, Faculty of Chemistry and Pharmacy, Sofia University, Sofia, Bulgaria.

Nature Communications

|April 28, 2017

Summary

This summary is machine-generated.

This study introduces a novel self-emulsification technique using narrow-range temperature cycling to repeatedly break down oil droplets. This method efficiently creates fine emulsions for applications like drug delivery.

More Related Videos

Microbubble Fabrication of Concave-porosity PDMS Beads

Microbubble Fabrication of Concave-porosity PDMS Beads

Published on: December 15, 2015

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Related Experiment Videos

Last Updated: Mar 3, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Microbubble Fabrication of Concave-porosity PDMS Beads

Microbubble Fabrication of Concave-porosity PDMS Beads

Published on: December 15, 2015

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Area of Science:

Physical Chemistry
Materials Science
Chemical Engineering

Background:

Self-emulsification typically relies on single-event changes like temperature shifts or phase inversions to create small oil droplets.
Existing methods for generating micro- and sub-micrometre oil droplets are limited and often energy-intensive.

Purpose of the Study:

To develop a new self-emulsification method utilizing controlled temperature cycling for enhanced droplet breakup.
To elucidate the mechanisms behind spontaneous droplet bursting induced by narrow-range temperature cycling.
To demonstrate the versatility and advantages of this novel emulsification approach.

Main Methods:

Employing narrow-range temperature cycling to induce repeated droplet breakup.
Investigating three distinct droplet bursting mechanisms, including lipid crystal dewetting.
Testing the method with diverse oil-surfactant combinations.

Main Results:

Successfully induced spontaneous bursting of larger oil droplets into thousands of smaller ones.
Identified and described novel droplet breakup mechanisms, including lipid crystal dewetting.
Demonstrated the method's efficacy across various oil-surfactant systems.

Conclusions:

Narrow-range temperature cycling offers a powerful, repeatable method for high-energy self-emulsification.
The technique enables low-surfactant emulsions suitable for temperature-sensitive compounds.
This scalable process is applicable to industrial emulsification and the fabrication of precisely sized particulate drug carriers.