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Updated: Jul 9, 2026
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Published on: April 7, 2015
Effects of B Value on Quantification of Rapid Diffusion Kurtosis Imaging in Normal and Acute Ischemic Brain Tissues
Ming-Chung Chou1, Cheng-Wen Ko, Yu-Hsien Chiu
1From the Departments of *Medical Imaging and Radiological Sciences, and †Healthcare Administration and Medical Informatics, Kaohsiung Medical University; ‡Department of Medical Research, Kaohsiung Medical University Hospital; §Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung; ∥Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei; ¶Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung; and #Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Purpose:
Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues.
Materials And Methods:
This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients. Three repeated DKI data with 6 high b values (500, 750, 1000, 1500, 2000, 3000 s/mm) were acquired from healthy subjects, whereas nonrepeated DKI data with 3 high b values (1000, 2000, 3000 s/mm) were acquired from ischemic stroke patients. The DKI datasets were decomposed into several rapid DKI datasets consisting of 1 b0 and 2 high b values for comparisons.
Results:
The results showed that b value significantly impacted the reproducibility and accuracy of DKI indices. The comparisons demonstrated that DKI with b = (0, 1000, 3000) s/mm exhibited more reproducible and accurate DKI indices than other DKI datasets in normal brain tissues, and similar results were noticed in acute ischemic brain tissue.
Conclusions:
We concluded that b value significantly impacted the quantification of DKI indices in both normal and acute ischemic brain tissues.
