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Relevant units of analysis for applied and basic research dealing with neglected transmissible diseases: The

Michel Tibayrenc1, Francisco J Ayala2

  • 1Maladies Infectieuses et Vecteurs Ecologie, Génétique, Evolution et Contrôle MIVEGEC (IRD 224-CNRS 5290-UM1-UM2), Institut de Rercherche pour le Développement (IRD), Montpellier, France.

Plos Neglected Tropical Diseases
|April 28, 2017
PubMed

Insights

The predominant clonal evolution (PCE) model provides a unified population genetics framework for micropathogens. This framework defines stable units for studying and controlling diseases like neglected tropical diseases.

Area of Science:

  • Population genetics
  • Evolutionary biology
  • Microbiology

Background:

  • The predominant clonal evolution (PCE) model offers a unified population genetics framework for diverse micropathogens.
  • It defines clonality based on population structure, specifically restrained genetic recombination.
  • This model enables the identification of stable, discrete units below the species level, such as clonal genotypes and near-clades.

Purpose of the Study:

  • To highlight the practical significance of the PCE model for studying and controlling neglected tropical diseases.
  • To make the PCE model's applications accessible to a broad scientific audience, including epidemiologists, field scientists, and clinicians.
  • To emphasize the utility of PCE-defined units for clinical, epidemiological, and evolutionary research.

Main Methods:

  • Review of existing literature on the PCE model.
  • Emphasis on the practical applications and implications of the PCE model.
  • Brief mention of the evolutionary and population genetics background.

Main Results:

  • The PCE model facilitates the definition of stable, clearly delimited units of analysis (clonal genotypes, near-clades).
  • These units are valuable for clinical and epidemiological studies, vaccine and drug design, and evolutionary research.
  • The model's properties are of strong interest for both applied and basic research.

Conclusions:

  • The PCE model provides a robust framework for understanding micropathogen populations.
  • Its practical applications are crucial for the control of neglected tropical diseases.
  • The PCE model's clear units of analysis enhance research in various biological and medical fields.

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