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Published on: June 20, 2020
Priority target conditions for algorithms for monitoring children's growth: Interdisciplinary consensus
Pauline Scherdel1,2,3, Rachel Reynaud4, Christine Pietrement5
1INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), early ORigins of the Child's Health and Development Team (ORCHaD), Paris Descartes University, Paris, France.
Insights
Experts reached a consensus on 8 priority conditions for monitoring children's growth, including celiac disease and Turner syndrome. This standardization aids in early detection of serious health issues.
Area of Science:
- Pediatric endocrinology
- Clinical algorithm development
- Growth monitoring
Background:
- Growth monitoring in children is crucial for early detection of serious conditions.
- Standardizing definitions of abnormal growth is essential for optimizing monitoring.
- Identifying priority target conditions is a prerequisite for standardization.
Purpose of the Study:
- To achieve expert consensus on priority target conditions for pediatric growth monitoring algorithms.
- To establish a standardized list for evaluating current growth monitoring tools.
Main Methods:
- A modified RAND/UCLA consensus method was employed.
- Expert groups from medical societies and parent associations participated.
- Experts reviewed and selected conditions based on predefined criteria for ideal priority targets.
Main Results:
- A strong agreement was reached on 8 priority conditions out of 133 possibilities.
- Selected conditions include celiac disease, Crohn disease, craniopharyngioma, juvenile nephronophthisis, Turner syndrome, growth hormone deficiency with pituitary stalk interruption syndrome, infantile cystinosis, and hypothalamic-optochiasmatic astrocytoma.
- The order of agreement for these conditions was documented.
Conclusions:
- The established national consensus provides a basis for evaluating current pediatric growth monitoring algorithms.
- The consensus methodology can be adapted for future international agreement on growth monitoring targets.
Background:
Growth monitoring of apparently healthy children aims at early detection of serious conditions through the use of both clinical expertise and algorithms that define abnormal growth. Optimization of growth monitoring requires standardization of the definition of abnormal growth, and the selection of the priority target conditions is a prerequisite of such standardization.
Objective:
To obtain a consensus about the priority target conditions for algorithms monitoring children's growth.
Methods:
We applied a formal consensus method with a modified version of the RAND/UCLA method, based on three phases (preparatory, literature review, and rating), with the participation of expert advisory groups from the relevant professional medical societies (ranging from primary care providers to hospital subspecialists) as well as parent associations. We asked experts in the pilot (n = 11), reading (n = 8) and rating (n = 60) groups to complete the list of diagnostic classification of the European Society for Paediatric Endocrinology and then to select the conditions meeting the four predefined criteria of an ideal type of priority target condition.
Results:
Strong agreement was obtained for the 8 conditions selected by the experts among the 133 possible: celiac disease, Crohn disease, craniopharyngioma, juvenile nephronophthisis, Turner syndrome, growth hormone deficiency with pituitary stalk interruption syndrome, infantile cystinosis, and hypothalamic-optochiasmatic astrocytoma (in decreasing order of agreement).
Conclusion:
This national consensus can be used to evaluate the algorithms currently suggested for growth monitoring. The method used for this national consensus could be re-used to obtain an international consensus.
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