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Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Mar 3, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Detecting Glaucoma With a Portable Brain-Computer Interface for Objective Assessment of Visual Function Loss.

Masaki Nakanishi¹, Yu-Te Wang², Tzyy-Ping Jung²

¹Visual Performance Laboratory, University of California-San Diego, La Jolla.

JAMA Ophthalmology

|April 28, 2017

Summary

This summary is machine-generated.

A new portable brain-computer interface (BCI) objectively assesses visual field loss in glaucoma. This BCI device shows promise in distinguishing glaucomatous from healthy eyes, offering a more reliable alternative to standard methods.

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Last Updated: Mar 3, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Published on: May 25, 2020

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A Single-Channel and Non-Invasive Wearable Brain-Computer Interface for Industry and Healthcare

A Single-Channel and Non-Invasive Wearable Brain-Computer Interface for Industry and Healthcare

Published on: July 7, 2023

Area of Science:

Ophthalmology
Neuroscience
Biomedical Engineering

Background:

Standard visual field loss assessment in glaucoma relies on subjective patient responses and lacks portability.
Objective and portable methods are needed for accurate visual function evaluation.

Purpose of the Study:

To develop and validate a portable brain-computer interface (BCI) for objective visual function assessment.
To compare the diagnostic performance of the BCI device with standard automated perimetry (SAP) in glaucoma patients.

Main Methods:

A case-control study involving 33 glaucoma patients and 17 healthy participants.
Development of a wearable BCI device integrating electroencephalogram (EEG) and electrooculogram (EOG) with a head-mounted display.
Comparison of BCI-derived multifocal steady-state visual-evoked potentials (MSVEPs) with SAP parameters for discriminating glaucomatous from healthy eyes.

Main Results:

The BCI device achieved a receiver operating characteristic curve area of 0.92 for global MSVEPs, outperforming SAP parameters (0.81 for mean deviation, 0.80 for mean sensitivity, 0.77 for pattern standard deviation).
The BCI device demonstrated good repeatability, with intraclass coefficients ranging from 0.74 to 0.92.
No significant differences were found between BCI and SAP for sectoral measurements.

Conclusions:

The portable BCI device effectively discriminates between glaucomatous and healthy eyes based on electrical brain responses.
The BCI shows potential as an objective and portable tool for visual field loss assessment.
Further research is warranted to explore home-based testing feasibility and longitudinal monitoring of visual function loss.