Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.6K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.6K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.5K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intereye differences in myopic macular degeneration, intraocular pressure and axial length: the Two-Continent Eye Study.

The British journal of ophthalmology·2026
Same author

Artificial intelligence-based retinal imaging for brain health assessment: a scoping review.

The Lancet. Digital health·2026
Same author

Functional and morphological alterations of light detection circuits in postmortem retina from donors with different stages of Alzheimer's-like pathology.

Communications biology·2026
Same author

A dataset of patients with isolated and syndromic optic neuropathies linked to RTN4IP1 genetic variants.

Scientific data·2026
Same author

Optic chiasmal neuritis: clinical features, aetiologies, MRI patterns and prognosis in a real-world cohort.

Journal of neurology·2026
Same author

Early corticosteroids predict visual whereas MRI lesion extent predicts retinal atrophy outcomes in MOG antibody-associated optic neuritis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same journal

Impact of Subretinal Drusenoid Deposits on Ellipsoid Zone-Related Thickness Metrics.

Investigative ophthalmology & visual science·2026
Same journal

Proteomic Profiling of Optic Nerves From SMOX-Deficient Mice Identifies Regulators of Neuroinflammation and Axonal Damage in Optic Neuritis.

Investigative ophthalmology & visual science·2026
Same journal

Aflibercept and Faricimab Equipotently Restore Endothelial Barrier Function.

Investigative ophthalmology & visual science·2026
Same journal

Spatial Decomposition of Longitudinal RNFL Maps Reveals Distinct Modes of Glaucomatous Progression With Structure-Function and Genetic Signatures.

Investigative ophthalmology & visual science·2026
Same journal

The CXXC1-IGFBP6 Axis Maintains Corneal Epithelial Differentiation via H3K4me3-Dependent Transcriptional Activation.

Investigative ophthalmology & visual science·2026
Same journal

Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.

Investigative ophthalmology & visual science·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K

Disrupted Eye Movements in Preperimetric Primary Open-Angle Glaucoma.

Raymond P Najjar1, Sourabh Sharma2, Morgane Drouet3

  • 1Singapore Eye Research Institute, Singapore 2The Ophthalmology and Visual Sciences Academic Clinical Program, Duke-National University of Singapore Medical School, Singapore.

Investigative Ophthalmology & Visual Science
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

Patients with early primary open-angle glaucoma (POAG) show abnormal saccadic eye movements, even before vision loss is detected. These findings suggest underlying neurological changes in the brain related to POAG.

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.5K

Related Experiment Videos

Last Updated: Mar 3, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

2.0K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.9K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.5K

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Science

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Ocular motor behavior may be altered in POAG, potentially as a compensatory mechanism for visual field deficits.
  • Early detection of POAG-related neurological changes is crucial for timely intervention.

Purpose of the Study:

  • To investigate saccadic eye movement characteristics in patients with preperimetric primary open-angle glaucoma (POAG).
  • To identify early ocular motor abnormalities in POAG before manifest visual field loss.

Main Methods:

  • A cross-sectional observational study comparing 16 patients with bilateral preperimetric POAG and 16 healthy controls.
  • Infrared oculography was used to measure visually guided horizontal prosaccades and antisaccades.
  • Key saccadic parameters including velocity, amplitude, gain, and antisaccade error rates were analyzed.

Main Results:

  • Patients with preperimetric POAG demonstrated significantly reduced average saccade velocity compared to controls.
  • POAG patients exhibited hypometric saccades with decreased amplitude and gain.
  • A higher percentage of antisaccade errors was observed in the POAG group.

Conclusions:

  • Preperimetric POAG is associated with altered saccadic eye movements, indicating potential early cortical and subcortical dysfunction.
  • These saccadic abnormalities may stem from subthreshold visual impairment or broader neurodegeneration linked to POAG.
  • Further research is needed to elucidate the neural underpinnings of these eye movement changes and the role of glaucoma medications.