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Progressive changes in non-coding RNA profile in leucocytes with age.

Maider Muñoz-Culla1,2, Haritz Irizar1,3, Ana Gorostidi4,5

  • 1Multiple Sclerosis Group, Biodonostia Health Research institute, San Sebastian, Spain.

Aging
|April 28, 2017
PubMed
Summary
This summary is machine-generated.

Aging involves immune cell decline and chronic inflammation. This study reveals that 69 small non-coding RNAs, including microRNAs and snoRNAs, change with age, particularly between 47-54 years.

Keywords:
aginghumanleucocytesmicroRNAnon-coding RNAregulationtranscriptome

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Area of Science:

  • Gerontology
  • Molecular Biology
  • Immunology

Background:

  • Elderly individuals experience immune cell deterioration and inflammaging.
  • Altered gene expression, including non-coding RNAs, is observed in aging peripheral blood mononuclear cells.

Purpose of the Study:

  • To investigate the expression patterns of small non-coding RNAs (microRNAs and snoRNAs) in healthy individuals across a wide age range.
  • To identify age-related changes in small non-coding RNA expression and their potential role in human aging.

Main Methods:

  • Analysis of small non-coding RNA expression (microRNAs and snoRNAs) in peripheral blood mononuclear cells from healthy individuals aged 24 to 79.
  • Statistical analysis to identify significant age-related expression trends and critical age periods.

Main Results:

  • The expression of 69 non-coding RNAs (56 microRNAs, 13 snoRNAs) significantly changes with chronological age.
  • A critical age window (47-54 years) was identified, showing pronounced shifts in age-related small non-coding RNA expression trends.
  • Age-related microRNAs target genes involved in immune, cell cycle, and cancer processes, processes linked to human aging.

Conclusions:

  • Human aging is characterized by progressive molecular changes, including alterations in small non-coding RNA expression.
  • Specific age ranges, such as 47-54 years, exhibit critical molecular shifts during the aging process.
  • Further research into age-related non-coding RNAs may provide insights into aging mechanisms and age-associated diseases.