Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.8K
3.8K
Types of RNA01:20

Types of RNA

10.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
10.1K
Types of RNA01:23

Types of RNA

73.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
73.4K
Translational Regulation01:29

Translational Regulation

730
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
730
Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

7.5K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of inspiratory muscle training on inspiratory muscle strength and exercise tolerance in patients with COPD: a meta-analysis and systematic review.

Frontiers in medicine·2026
Same author

Engineering Stable Thallium Immobilization through Synergistic Microbial-Mineral Partnership in Fe-Doped Biogenic Manganese Oxides.

Environmental research·2026
Same author

Gemcitabine enhanced the sensitivity of colorectal cancer to anti-PD-L1 therapy by promoting lactylation.

International immunopharmacology·2026
Same author

EAD-MS/MS-driven intelligent structure prediction and NMR fast structure elucidation framework for nitazene analogs.

Forensic science international·2026
Same author

GraphLooper: predicting chromatin loops based on hierarchical multi-view graph pooling method.

Briefings in bioinformatics·2026
Same author

Acid-resistant ferrihydrite-spent grain composites for enhanced as and Sb removal from acid mine drainage.

Environmental research·2026

Related Experiment Video

Updated: Mar 3, 2026

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.5K

Long noncoding RNA: a crosslink in biological regulatory network.

Yuwei Zhang1, Yang Tao1, Qi Liao1

  • 1Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, Ningbo, Zhejiang, China.

Briefings in Bioinformatics
|April 28, 2017
PubMed
Summary

Long noncoding RNAs (lncRNAs) regulate gene expression through complex mechanisms. This review explores lncRNA interactions with other molecules and analyzes bioinformatics methods for deciphering lncRNA regulatory networks.

More Related Videos

Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.8K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K

Related Experiment Videos

Last Updated: Mar 3, 2026

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

24.5K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

88.8K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.4K

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Long noncoding RNAs (lncRNAs) are functional RNA molecules exceeding 200 nucleotides.
  • lncRNAs are recognized for their significant, yet complex, roles in gene expression regulation.
  • The precise molecular mechanisms and interaction networks of lncRNAs remain an active area of research.

Purpose of the Study:

  • To review known associations between lncRNAs and other biological molecules.
  • To present various bioinformatics approaches for predicting and analyzing lncRNA interactions.
  • To illustrate lncRNA regulatory network analysis through a case study of linc00460.

Main Methods:

  • Literature review of lncRNA functions and interactions.
  • Description of bioinformatics tools and algorithms for lncRNA analysis.
  • Case study involving lncRNA linc00460 network elucidation.

Main Results:

  • Overview of established lncRNA-molecule interactions.
  • Demonstration of bioinformatics pipeline for lncRNA network analysis.
  • Detailed analysis of the linc00460 regulatory network.

Conclusions:

  • lncRNA interactions are diverse and crucial for gene regulation.
  • Bioinformatics significantly advances the study of lncRNA networks.
  • Understanding lncRNA networks provides insights into transcriptome regulation.