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Strong association between cardiorespiratory fitness and serum lipoprotein subclass pattern in prepubertal healthy

G K Resaland1,2, T Rajalahti3, E Aadland1

  • 1Faculty of Teacher Education and Sports, Western Norway University of Applied Sciences, Sogndal, Norway.

Scandinavian Journal of Medicine & Science in Sports
|April 28, 2017
PubMed

Insights

Cardiorespiratory fitness (CRF) in children is linked to specific lipoprotein patterns, indicating better cardiovascular health. A practical field test, the Andersen test, effectively measures CRF and cardiovascular health in children.

Area of Science:

  • Pediatric Cardiology
  • Lipid Metabolism
  • Exercise Physiology

Background:

  • Cardiorespiratory fitness (CRF) is crucial for children's cardiovascular health.
  • Understanding the relationship between lipoprotein subclasses and CRF can offer insights into cardiovascular risk factors.
  • Previous research has explored lipoprotein profiles in adults, but less is known about these associations in healthy children.

Purpose of the Study:

  • To identify lipoprotein subclass patterns associated with cardiorespiratory fitness (CRF) in healthy children.
  • To investigate the relationship between various lipoprotein features and CRF measured by different methods.
  • To determine if CRF is a reliable indicator of cardiovascular health in children through lipoprotein analysis.

Main Methods:

  • Serum lipoprotein subclasses, concentrations, and particle sizes were measured in 94 Norwegian children using high-performance liquid chromatography (HPLC).
  • Multivariate regression analysis was employed, using 24 lipoprotein features and including BMI and gender as covariates.
  • CRF was assessed using both peak oxygen consumption (VO2peak) via a treadmill test and the 10-minute Andersen intermittent running field test.

Main Results:

  • CRF positively correlated with large high-density lipoprotein (HDL) particles and negatively with very small HDL particles, chylomicrons, and triglycerides.
  • Cardiorespiratory fitness showed a negative association with the size and concentration of very low-density lipoprotein (VLDL) particles.
  • A significant association was found between CRF (measured by VO2peak or Andersen test) and a lipoprotein subclass pattern indicative of better cardiovascular health.

Conclusions:

  • A distinct lipoprotein subclass pattern is associated with higher cardiorespiratory fitness in children, suggesting improved cardiovascular health.
  • The Andersen intermittent running field test is a practical and valid measure of CRF in children, less influenced by BMI than VO2peak.
  • These findings underscore the importance of high CRF for children's cardiovascular well-being and highlight specific lipoprotein markers as indicators.

Keywords:
Andersen testVO2peakaerobic fitnesslipoprotein subclassesmetabolic healthmultivariate pattern analysisselectivity ratio

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