Related Experiment Video

Updated: Mar 3, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

6.1K

[The Role of MicroRNAs in Colorectal Cancer]

Sang Wook Kim1

  • 1Division of Gastroenterology, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|April 28, 2017
PubMed

Insights

MicroRNAs (miRNAs) play crucial roles in colorectal cancer (CRC) development and progression. These small RNAs show potential as diagnostic biomarkers and therapeutic targets for CRC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a major global health concern, driven by genetic alterations.
  • MicroRNAs (miRNAs), small non-coding RNAs, regulate gene expression and are implicated in tumorigenesis.
  • miRNAs are increasingly recognized for their roles in CRC development, including inflammation, cell cycle, and apoptosis.

Purpose of the Study:

  • To review the diagnostic and therapeutic applications of miRNAs in colorectal cancer.
  • To highlight the potential of miRNAs as biomarkers for CRC detection and prognosis.
  • To discuss the use of miRNA modulation for CRC treatment strategies.

Main Methods:

  • Literature review of recent studies on miRNAs in CRC.
  • Analysis of miRNA expression patterns in CRC tissues.
  • Investigation of miRNA-mediated gene regulation in cancer pathways.

Main Results:

  • Specific miRNA expression profiles can differentiate CRC from other colon diseases.
  • miRNAs can target oncogenes and tumor suppressor pathways relevant to CRC.
  • Restoring tumor-suppressive miRNAs or inhibiting oncogenic miRNAs shows therapeutic promise for CRC.

Conclusions:

  • miRNAs are significant players in colorectal cancer pathogenesis.
  • miRNAs hold substantial potential as diagnostic biomarkers for CRC.
  • Targeting miRNAs offers a promising avenue for novel CRC therapeutic interventions.
Keywords:
Colorectal cancerMicroRNAs

More Related Videos

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts10:33

Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts

Published on: April 29, 2014

11.5K
MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

459

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.2K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K