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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

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Higher coronary artery calcification score is associated with adverse prognosis in patients with stable angina

Renrong Wang1, Xiaoxiao Liu1, Chunxia Wang1

  • 1Department of Cardiology, Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi 214002, China.

Journal of Thoracic Disease
|April 29, 2017
PubMed

Insights

Coronary artery calcification (CAC) scores predict major adverse cardiac events (MACE) in stable angina patients. Percutaneous coronary intervention (PCI) did not impact prognosis regardless of CAC score levels.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Prognostics

Background:

  • Coronary artery calcification (CAC) signifies atherosclerotic lesions and predicts outcomes in coronary artery disease (CAD).
  • This study investigates the prognostic value of CAC scoring in patients with stable angina pectoris (SAP).

Purpose of the Study:

  • To evaluate the predictive capability of Coronary Artery Calcification (CAC) scores for prognosis in patients diagnosed with Stable Angina Pectoris (SAP).

Main Methods:

  • 106 SAP patients underwent multi-slice computed tomography (MSCT) for CAC scoring using the Agatston algorithm.
  • Patients were stratified into lower (≤300) and higher (>300) CAC score groups.
  • Major adverse cardiac events (MACE) and non-event survival were tracked and analyzed against clinical characteristics and CAC scores.

Main Results:

  • CAC scores positively correlated with age and creatinine levels.
  • Higher CAC scores were associated with increased rates of percutaneous coronary intervention (PCI), MACE, and multi-vessel disease.
  • CAC score was identified as a significant risk factor for reduced no-event survival time (HR 3.06).

Conclusions:

  • CAC scores strongly predict MACE in SAP patients.
  • Percutaneous coronary intervention (PCI) did not demonstrate a significant impact on clinical prognosis in either high or low CAC score groups.
Abstract

Keywords:
Coronary artery calcification score (CAC score)major adverse cardiac events (MACE)prognosisstable angina pectoris (SAP)

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