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Sunitinib specifically augments glucose-induced insulin secretion

Stefan Z Lutz1, Axel Ullrich2, Hans-Ulrich Häring1

  • 1German Center for Diabetes Research (DZD e.V.), Germany; Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Center Munich at the Eberhard-Karls-University of Tübingen, Germany; University Hospital Tübingen, Internal Medicine IV, Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Otfried-Müller-Str. 10, 72076 Tübingen, Germany.

Cellular Signalling
|April 29, 2017
PubMed
Summary

The tyrosine kinase inhibitor sunitinib directly stimulates glucose-induced insulin secretion (GIIS) in beta cells. This action may explain sunitinib's beneficial effects on blood glucose control in diabetic patients.

Keywords:
FFAR1GLP-1RInsulin secretionPKASunitinibcAMP

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