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Pregnancy and bile acid disorders.

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Summary

This review covers intrahepatic cholestasis of pregnancy (ICP), a common pregnancy-specific bile acid disorder. It explores ICP

Keywords:
bile acidcholestasisliver diseasepregnancy

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Area of Science:

  • Obstetrics and Gynecology
  • Hepatology
  • Maternal-Fetal Medicine

Background:

  • Pregnancy involves significant metabolic and immunological adaptations.
  • Preexisting conditions can worsen, and new susceptibilities may emerge.
  • Cholestatic diseases, marked by high bile acids, need careful pregnancy monitoring.

Purpose of the Study:

  • To review current knowledge on intrahepatic cholestasis of pregnancy (ICP).
  • To examine ICP etiology and mechanisms linked to adverse pregnancy outcomes.
  • To discuss management of preexisting cholestatic conditions during pregnancy.

Main Methods:

  • Literature review of recent advances in cholestasis of pregnancy.
  • Analysis of disease etiology and adverse pregnancy outcome mechanisms.
  • Synthesis of information on management and novel therapeutics.

Main Results:

  • Intrahepatic cholestasis of pregnancy (ICP) is the most common bile acid disorder in pregnancy.
  • ICP is associated with adverse pregnancy outcomes, including fetal demise.
  • Review covers management of preexisting cholestatic conditions like PSC, PBC, biliary atresia, and Alagille syndrome.

Conclusions:

  • Understanding ICP etiology and mechanisms is crucial for managing pregnancy complications.
  • Current treatments and emerging therapeutics offer improved management options.
  • Comprehensive review aids clinicians in managing cholestasis during pregnancy.