CD4+ T-cell Depletion Prevents GVHD

    Cancer Discovery
    |April 29, 2017
    PubMed

    Temporary removal of CD4+ T cells after an allogeneic hematopoietic stem-cell transplant leads to changes in the nature of CD8+ T cells that, according to a mouse study, help prevent graft-versus-host disease without jeopardizing the therapy's potential to eliminate leukemia or lymphoma.