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Association of High-Density Lipoprotein Subclasses with Carotid Intima-Media Thickness: Shimane CoHRE Study

Yoshitomo Notsu1, Shozo Yano1,2, Miwako Takeda2

  • 1Department of Laboratory Medicine, Shimane University.

Journal of Atherosclerosis and Thrombosis
|April 29, 2017
PubMed

Insights

High-density lipoprotein (HDL) subclasses HDL2-C and HDL3-C were not significantly associated with carotid atherosclerosis in a Japanese population. Further research is needed to clarify the role of HDL subclasses in predicting atherosclerotic disorders.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Lipid Metabolism

Background:

  • Subclasses of high-density lipoprotein (HDL) are increasingly recognized as potential biomarkers for atherosclerotic disorders.
  • Predictive value of HDL subclasses, specifically HDL2-cholesterol (HDL2-C) and HDL3-cholesterol (HDL3-C), for atherosclerosis requires further investigation.

Purpose of the Study:

  • To investigate the association between HDL2-C and HDL3-C levels and carotid intima-media thickness (IMT) in a Japanese population.
  • To evaluate the utility of a novel homogenous assay for quantifying HDL-C subclasses in relation to atherosclerosis markers.

Main Methods:

  • A cross-sectional study involving 657 Japanese subjects (mean age 73 years).
  • Serum HDL-C and HDL3-C were quantified using a homogenous assay; HDL2-C was calculated.
  • Carotid intima-media thickness (max-IMT) and plaque score (PS) were assessed via ultrasonography.

Main Results:

  • HDL3-C showed an inverse association with age in both men and women.
  • Simple regression indicated an inverse association between max-IMT and HDL3-C, but not HDL2-C.
  • Multiple regression analysis, after adjusting for age, revealed no significant association between HDL3-C or HDL2-C and max-IMT or PS.

Conclusions:

  • Neither HDL2-C nor HDL3-C was found to be a significant predictor of carotid atherosclerosis in this Japanese cohort.
  • The study suggests that HDL subclasses may not be reliable biomarkers for carotid atherosclerosis in this population.
Abstract

Keywords:
AtherosclerosisCholesterolHigh-density lipoprotein (HDL)Intima-media thickness (IMT)

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