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Updated: Mar 3, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Engineering catalytic coordination space in a chemically stable Ir-porphyrin MOF with a confinement effect inverting
Yingxia Wang1, Hao Cui1, Zhang-Wen Wei1
1MOE Laboratory of Bioinorganic and Synthetic Chemistry , Lehn Institute of Functional Materials , School of Chemistry and Chemical Engineering , Sun Yat-sen University , Guangzhou 510275 , China . Email: zhli99@mail.sysu.edu.cn ;
Abstract:
An iridium-porphyrin ligand, Ir(TCPP)Cl (TCPP = tetrakis(4-carboxyphenyl)porphyrin), has been utilized to react with HfCl4 to generate a stable Ir(iii)-porphyrin metal-organic framework of the formula [(Hf6(μ3-O)8(OH)2(H2O)10)2(Ir(TCPP)Cl)3]·solvents (Ir-PMOF-1(Hf)), which possesses two types of open cavities (1.9 × 1.9 × 1.9 and 3.0 × 3.0 × 3.0 nm3) crosslinked through orthogonal channels (1.9 × 1.9 nm2) in three directions. The smaller cavity is surrounded by four catalytic Ir(TCPP)Cl walls to form a confined coordination space as a molecular nanoreactor, while the larger one facilitates reactant/product feeding and release. Therefore, the porous Ir-PMOF-1(Hf) can act as a multi-channel crystalline molecular flask to promote the carbenoid insertion reaction into Si-H bonds, featuring high chemoselectivity towards primary silanes among primary, secondary and tertiary silanes under heterogeneous conditions that are inaccessible by conventional homogeneous catalysts.
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