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Islet cell transplant: Update on current clinical trials
Christian Schuetz1, James F Markmann1
1Islet transplantation laboratory, Division of Transplantation, Department of Surgery.
Current Transplantation Reports
|April 29, 2017
Summary
Clinical islet transplantation is now standard care for select patients with type 1 diabetes facing severe hypoglycemia or kidney failure. This review covers current outcomes and future advancements in beta cell therapy.
Area of Science:
- Endocrinology
- Transplantation immunology
- Regenerative medicine
Background:
- Clinical islet transplantation has evolved from an experimental approach to a standard therapy for specific patient populations over the past 15 years.
- The procedure is reserved for individuals with type 1 diabetes complicated by severe hypoglycemia or end-stage renal disease due to the risks associated with necessary systemic immunosuppression.
Purpose of the Study:
- To review the current outcomes of clinical islet transplantation.
- To explore ongoing and future advancements in beta cell therapy.
Main Methods:
- Literature review of clinical islet transplantation studies.
- Analysis of current outcomes and future trends in beta cell replacement therapy.
Main Results:
- Islet transplantation is an established treatment for carefully selected patients with type 1 diabetes.
- Ongoing research focuses on improving graft survival and reducing immunosuppression requirements.
Conclusions:
- Clinical islet transplantation offers a viable therapeutic option for specific patients with type 1 diabetes.
- Future directions include refining beta cell therapy to enhance efficacy and broaden patient eligibility.
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