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Updated: Mar 3, 2026

Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis
05:30

Live-cell Imaging of Lysosomal Membrane Permeabilization During Necroptosis

Published on: November 14, 2025

497

Necroptosis and Cancer

Ayaz Najafov1, Hongbo Chen1,2, Junying Yuan1

  • 1Department of Cell Biology, Harvard Medical School, 240 Longwood Ave. Boston, MA 02115.

Trends in Cancer
|April 29, 2017
PubMed

Insights

Necroptosis, a programmed cell death, is implicated in cancer progression and inflammation. Understanding its role is key to developing novel cancer therapies targeting this cell death pathway.

Area of Science:

  • * Molecular Biology
  • * Immunology
  • * Oncology

Background:

  • * Necroptosis is a programmed lytic cell death pathway implicated in inflammatory disorders.
  • * Deregulation of programmed cell death and inflammation are significant factors in cancer development.
  • * Investigating necroptosis in cancer is crucial due to its role in metastasis and T cell death.

Purpose of the Study:

  • * To review the interplay between necroptosis and cancer.
  • * To outline key biological questions for targeting necroptosis in cancer therapy.

Main Methods:

  • * Literature review of recent studies on necroptosis and cancer.
  • * Analysis of the biological roles and therapeutic potential of necroptosis.

Main Results:

  • * Necroptosis can promote cancer metastasis and T cell death.
  • * Loss of RIPK3 expression is a mechanism for escaping necroptosis in some cancers.
  • * Necroptosis represents a promising, yet under-investigated, target for cancer therapies.

Conclusions:

  • * Further research into necroptosis's biological role in carcinogenesis is warranted.
  • * Targeting necroptosis holds potential for novel cancer treatment strategies.
Keywords:
cancercross-primingimmunitymetastasisnecroptosistherapy

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