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Decreasing Estimated Glomerular Filtration Rate Is Associated With Increased Risk of Hospitalization After Kidney
F M Keong1, Y A Afshar1, S O Pastan2,3
1Rollins School of Public Health, Emory University, Atlanta, GA.
Kidney International Reports
|April 29, 2017
Summary
Declining kidney function after transplant increases hospitalization risk. Lower estimated glomerular filtration rate (eGFR) is linked to more frequent hospital admissions post-kidney transplant, highlighting a key factor for patient monitoring.
Area of Science:
- Nephrology
- Transplantation Medicine
- Clinical Epidemiology
Background:
- Decreased renal function post-kidney transplant correlates with higher risks of cardiovascular disease, graft loss, and mortality.
- The association between declining renal function and post-transplant hospitalization requires further investigation.
Purpose of the Study:
- To investigate the relationship between declining renal function and hospitalization rates in adult kidney transplant recipients.
Main Methods:
- Analysis of adult, first-time kidney transplant recipients from 2004-2006 using the United Network for Organ Sharing database.
- Generalized linear models were used to assess the association between estimated glomerular filtration rate (eGFR) at 6 months post-transplant and hospitalization rates in the subsequent year.
Main Results:
- A significant association was found between lower eGFR and increased hospitalization rates.
- For every 10 ml/min/1.73m² decrease in eGFR, there was an 11% increase in the hospitalization rate (p <0.001).
- Lower eGFR post-transplant was linked to a higher incidence of late hospitalizations.
Conclusions:
- Declining eGFR after kidney transplantation is a significant predictor of increased hospitalizations.
- Identifying patients with declining eGFR can aid in preventing morbidity and mortality associated with post-transplant hospitalizations.
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