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Cutaneous Toxicities From Transplantation-Related Medications

M Ilyas1, O R Colegio2, B Kaplan3

  • 1Department of Dermatology, Mayo Clinic Arizona, Scottsdale, AZ.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|April 29, 2017
PubMed

Insights

Solid organ transplant recipients often experience nonmalignant skin changes due to medications. Early identification and management of these drug toxicities are crucial for patient care.

Area of Science:

  • Dermatology
  • Transplantation Medicine
  • Pharmacology

Background:

  • Limited data exists on nonmalignant skin changes post-solid organ transplantation.
  • Skin toxicities are common adverse effects of immunosuppressive and transplant-related medications.

Purpose of the Study:

  • To review and discuss nonmalignant cutaneous manifestations of transplant-related medications.
  • To provide guidance for identifying and managing drug-induced skin toxicities in transplant recipients.

Main Methods:

  • Literature review of transplant-related medications and their dermatologic side effects.
  • Discussion of specific drug classes including antithymocyte globulins, systemic steroids, calcineurin inhibitors, antiproliferatives, mTOR inhibitors, and others.

Main Results:

  • Various immunosuppressive and anti-rejection drugs can cause a spectrum of nonmalignant skin conditions.
  • Understanding the presentation, severity, and prognosis of these toxicities is essential.

Conclusions:

  • Effective management of drug-induced skin toxicities is vital to reduce morbidity in solid organ transplant recipients.
  • Healthcare providers must be vigilant in recognizing and treating these dermatologic side effects.
Keywords:
clinical research/practicecomplicationdermatologydrug toxicityhealth services and outcomes researchimmunosuppressantimmunosuppression/immune modulationpharmacology

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