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The prevalence of hypertension in children with renal scars

Nakysa Hooman1, Roya Isa-Tafreshi2, Seyed-Hassan Mostafavi3

  • 1Department of Pediatric Nephrology, Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran - hooman.n@iums.ac.ir.

Minerva Pediatrica
|April 29, 2017
PubMed

Insights

Early blood pressure abnormalities in children with renal scars from urinary tract infections are detectable with 24-hour ambulatory blood pressure monitoring (24-H ABPM). This monitoring aids in the early detection of hypertension and pre-hypertension in this vulnerable pediatric population.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in Children
  • Hypertension Research

Background:

  • Hypertension (HTN) is a known sequela of renal scarring, whether congenital or acquired.
  • Early detection of blood pressure abnormalities is crucial in children with a history of urinary tract infections (UTIs) and renal scarring.

Purpose of the Study:

  • To assess early blood pressure abnormalities in children with a history of UTIs and varying degrees of renal scarring.
  • To evaluate the utility of 24-hour ambulatory blood pressure monitoring (24-H ABPM) in this pediatric cohort.

Main Methods:

  • A cohort of 60 children (aged 5-15 years) with a history of febrile UTIs and renal scarring underwent 24-H ABPM.
  • Updated classification criteria for 24-H ABPM were employed to interpret the findings.

Main Results:

  • Abnormal blood pressure patterns, including masked hypertension (5%), hypertension (8.4%), and white coat hypertension (11.7%), were identified.
  • Pre-hypertension was observed in 23.3% of the children.
  • Significant correlations were found between abnormal blood pressure and the severity of renal parenchymal scar, vesicoureteral reflux, microalbuminuria, and carotid intima-media thickness.

Conclusions:

  • 24-H ABPM is effective for the early detection of hypertension and pre-hypertension in children with severe renal scars and a history of UTIs.
  • This monitoring approach can identify subclinical cardiovascular risks in children with a history of renal scarring due to UTIs.
Abstract

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