Exposure to SVOCs from Inhaled Particles: Impact of Desorption

Inhaled semivolatile organic compounds (SVOCs) are simultaneously present in gas and particle phases. Particles desorb a fraction of their SVOCs moving through the human respiratory tract (RT). Quantifying such desorption is challenging but important since gas- and particle-phase SVOCs deposit in different locations in the RT, encountering different cell populations with varying health consequences. This paper presents a mass transfer model to quantify this desorption process in the head, tracheobronchial, and alveolar regions of the RT. The desorption of SVOCs from inhaled particles can be gauged using the ratio of particle residence time to the time required to achieve particle/gas equilibrium. Results indicate that the larger this ratio is, the more likely particles desorb the SVOCs they carry. For particles smaller than 0.5 μm diameter and SVOCs with a particle/gas partition coefficient (unitless) of 10¹⁰, accounting for desorption reduces the estimated particle-phase SVOC concentrations in the alveolar region by more than 35%; the reduction is almost 700% for 0.05 μm diameter particles. In hypothetical scenarios representing common indoor and outdoor situations, neglecting desorption significantly overestimates the concentration of ultrafine particle associated SVOCs in the alveolar region. This model is a preliminary step toward more nuanced estimates of exposure to inhaled SVOCs.