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Related Concept Videos

Mass Analyzers: Common Types01:19

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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A "Brick Mass Spectrometer" Driven by a Sinusoidal Frequency Scanning Technique.

Ting Jiang1, Hongjia Zhang2, Yang Tang1

  • 1State Key Laboratory of Explosion Science and Technology, School of Life Science, Beijing Institute of Technology , Beijing 100081, China.

Analytical Chemistry
|April 29, 2017
PubMed
Summary
This summary is machine-generated.

A new miniature mass spectrometer uses a novel frequency scanning technique. This innovation reduces size and power while enhancing mass range and resolution for portable chemical analysis.

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Area of Science:

  • Analytical Chemistry
  • Instrumentation Science
  • Physical Chemistry

Background:

  • Miniaturization of mass spectrometers is crucial for portable analytical applications.
  • Conventional mass spectrometers often rely on bulky components and high power consumption.
  • Developing compact and efficient mass analysis systems remains a significant challenge.

Purpose of the Study:

  • To develop and characterize a novel
  • brick
  • size miniature mass spectrometer (BMS).
  • To introduce and validate a new sinusoidal frequency scanning technique for ion trap manipulation.
  • To assess the analytical performance, including stability, sensitivity, mass resolution, and mass range, of the developed BMS.

Main Methods:

  • Development of a compact linear ion trap mass spectrometer.
  • Implementation of a sinusoidal frequency scanning technique for ion manipulation, replacing traditional voltage scanning.
  • Coupling the BMS with both in-vacuum plasma ionization and electrospray ionization sources.
  • Characterization of stability, sensitivity, mass resolution, and mass range.

Main Results:

  • Successful development and characterization of a miniature mass spectrometer with dimensions of 28 cm × 21 cm × 16 cm.
  • Demonstration that the sinusoidal frequency scanning technique improves mass range and resolution compared to conventional methods.
  • The BMS, coupled with different ionization sources, effectively analyzed both volatile and nonvolatile samples.
  • Reduced size and power consumption were achieved without compromising analytical performance.

Conclusions:

  • The developed miniature mass spectrometer, utilizing a novel frequency scanning technique, offers a significant advancement in portable analytical instrumentation.
  • This technology paves the way for further miniaturization, potentially leading to "cell" mass spectrometers.
  • The BMS demonstrates improved analytical capabilities, making it suitable for diverse field applications.