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The HIV tat gene induces dermal lesions resembling Kaposi's sarcoma in transgenic mice
J Vogel1, S H Hinrichs, R K Reynolds
1Laboratory of Molecular Virology, National Cancer Institute, Bethesda, Maryland 20892.
Nature
|October 13, 1988
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.
When the human immunodeficiency virus transactivating gene under the control of the viral regulatory region is introduced into the germline of mice, skin lesions are induced that resemble Kaposi's sarcoma seen in AIDS. Our findings indicate that HIV could play a direct part in causing cancer.